## Abstract Formalinโfixed, paraffinโembedded biopsies of 193 women with primary breast cancer followedโup for over 10 years were analysed immunohistochemically for the expression of p53 protein. Altogether, 58% (113/193) of the tumors were positive for p53 protein. Overโexpression of p53 was assoc
P53 expression in breast cancer
โ Scribed by Giorgio Cattoretti; Franco Rilke; Salvatore Andreola; Lucia D'Amato; Domenico Delia
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 809 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series of 130 breast adenocarcinomas. This study intended to investigate whether the frequency of the altered expression of the tumour suppressor gene p53 and the overexpression of the oncogene c-erbB-2 in breast
The p53 locus on the short arm of chromosome I 7 at I7p 13. I was examined for loss of heterozygosity, mutation, rnRNA and protein expression in 60 primary breast cancers. Allele loss around the p53 locus was detected in 19/45 informative turnours (42%). p53 mutations in the evolutionarily conserved