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p53 Inactivation is a Rare Event in Familial Breast Tumors Negative for BRCA1 and BRCA2 Mutations

✍ Scribed by Elisa Sensi; Mariella Tancredi; Paolo Aretini; Giovanna Cipollini; A. Giuseppe Naccarato; Paolo Viacava; Generoso Bevilacqua; Maria A. Caligo


Book ID
111574948
Publisher
Springer US
Year
2003
Tongue
English
Weight
90 KB
Volume
82
Category
Article
ISSN
0167-6806

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Germline mutations of the BRCA1-associat
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## Abstract BARD1 (BRCA1‐associated RING domain) was identified by yeast two‐hybrid screening as a protein interacting with BRCA1. Somatic and germline mutations of __BARD1__ have been detected in sporadic breast, ovarian, and endometrial cancers. The present study represents the first description