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The PALB2 Gene Is a Strong Candidate for Clinical Testing in BRCA1- and BRCA2-Negative Hereditary Breast Cancer

✍ Scribed by Janatova, M.; Kleibl, Z.; Stribrna, J.; Panczak, A.; Vesela, K.; Zimovjanova, M.; Kleiblova, P.; Dundr, P.; Soukupova, J.; Pohlreich, P.


Book ID
121761393
Publisher
American Association for Cancer Research
Year
2013
Tongue
English
Weight
844 KB
Volume
22
Category
Article
ISSN
1055-9965

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## Abstract BARD1 (BRCA1‐associated RING domain) was identified by yeast two‐hybrid screening as a protein interacting with BRCA1. Somatic and germline mutations of __BARD1__ have been detected in sporadic breast, ovarian, and endometrial cancers. The present study represents the first description