Based on a previous finding that amplification of the c-erbB-2 oncogene and alteration of p53 are strongly associated in most aggressive breast tumours, the present study investigated whether microsatellite instability (MI) might also be associated with this tumour phenotype. Nine polymorphic micros
β¦ LIBER β¦
p53 Expression is Decreased in Primary Breast Carcinomas with Microsatellite Instability
β Scribed by Claudia Pizzi; Luigi Panico; Laura De Marchis; Paolo Mastranzo; Massimo Di Maio; Cristina D'amico; Gennaro Limite; Guido Pettinato; Sergio Cocozza; Angelo Raffaele Bianco; Alma Contegiacomo
- Book ID
- 110341270
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 154 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0167-6806
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## Abstract This study investigates the molecular features of metastasis in sporadic colon carcinomas with highβlevel microsatellite instability (MSIβH). DNA from 51 regions from 10 MSIβH metastatic carcinomas and 26 corresponding metastases was analyzed for mutations in __TGFBRII__, __IGFIIR__, __