Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability
โ Scribed by Biden, Kelli G; Simms, Lisa A; Cummings, Margaret; Buttenshaw, Ron; Schoch, Estelle; Searle, Jeffrey; Gobe, Glenda; Jass, Jeremy R; Meltzer, Stephen J; Leggett, Barbara A
- Book ID
- 110061865
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 728 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## BACKGROUND. Widespread microsatellite instability (MSI) occurs in nearly 15% of sporadic colorectal cancers. Large bowel carcinomas with high-frequency MSI (MSI-H) (instability at ี 30% of microsatellite loci) are believed to display distinctive pathologic features and to behave less aggressive
Using western blotting and immunochemical analysis, we investigated alterations in the expression of the apoptosis-related proteins bcl-2, bax, and bcl-X in colonic adenocarcinomas induced by subcutaneous injection of azoxymethane (AOM) (15 mg/kg body weight weekly for 2 wk) into male Sprague-Dawley