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p53 codon 72 polymorphism in bladder cancer – no evidence of association with increased risk or invasiveness

✍ Scribed by Törüner, Gökçe A. ;Uçar, Ahmet ;Tez, Mesut ;Çetinkaya, Mesut ;Özen, Haluk ;Özçelik, Tayfun


Publisher
Springer
Year
2001
Tongue
English
Weight
81 KB
Volume
29
Category
Article
ISSN
0300-5623

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A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a