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Distributions of p53 codon 72 polymorphism in bladder cancer - proline form is prominent in invasive tumor

✍ Scribed by Chen, W.-C. ;Tsai, F.-J. ;Wu, J.-Y. ;Wu, H.-C. ;Lu, H.-F. ;Li, C.-W.

Publisher: Springer
Year: 2000
Tongue: English
Weight: 79 KB
Volume: 28
Category: Article
ISSN: 0300-5623
DOI: 10.1007/s002400000117

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A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ