## Abstract A single nucleotide polymorphism (SNP) at codon 72 of the __p53__ gene (Arg72Pro) alters the p53 protein structure and affects its activity. We investigated this SNP in relation to colorectal adenoma and cancer among men and women from caseβcontrol studies nested within the Nurses' Heal
P53 Arg72Pro Polymorphism in Gastric Cancer Patients
β Scribed by Lessileia Gomes de Souza; Jacqueline Miranda de Lima; Ismael Dale Cotrim Guerreiro da Silva; Nora Manoukian Forones
- Book ID
- 107574675
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 109 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1941-6628
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## Abstract No clear consensus has been reached on the __TP53__ Arg72Pro polymorphism (G12139C) and lung cancer risk. Thus, a metaβanalysis was conducted to summarize the possible association. There was no statistical association between 12139C (Pro allele) and lung cancer risk in Caucasians compar
## Abstract It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the wellβknown Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actuall