Association of p53 Arg72Pro polymorphism and β-catenin accumulation in mycosis fungoides
✍ Scribed by B. Bellei; C. Cota; A. Amantea; L. Muscardin; M. Picardo
- Book ID
- 108669080
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 269 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0007-0963
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A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ
## Abstract Recent studies have demonstrated that increased expression of coding region determinant‐binding protein (CRD‐BP) in response to β‐catenin signaling leads to the stabilization of β‐TrCP1, a substrate‐specific component of SCF E3 ubiquitin ligase complex, resulting in an accelerated degra