## Communicated by Dvorah Abeliovich Germline mutations in the BRCA1 and BRCA2 genes confer a high lifetime risk of developing breast and other cancers; however, remarkable differences exist regarding disease manifestation in mutation carriers. It has been suggested that other genetic and/or enviro
The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses’ health studies
✍ Scribed by David G. Cox; Dwayne Deer; Qun Guo; Shelley S. Tworoger; Susan E. Hankinson; David J. Hunter; Immaculata De Vivo
- Publisher
- Springer Netherlands
- Year
- 2007
- Tongue
- English
- Weight
- 135 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0957-5243
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A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a
## Abstract Polymorphisms at loci controlling cellular processes such as cell cycle, DNA repair, and apoptosis may modulate the risk of cancer. We examined the association of two linked polymorphisms (G4C14–A4T14) at __p73__ and one polymorphism (309G > T) at __MDM2__ promoter with the risk of leuk