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P4-180 The roles of phorbol ester targets MUNC13 and MUNC18 in vesicular trafficking and processing of the Alzheimer's disease amyloid precursor protein

โœ Scribed by Causevic, Mirsada; Betz, Andrea; Brose, Nils; Burgoyne, Robert D.; Gandy, Sam


Book ID
122495132
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
160 KB
Volume
25
Category
Article
ISSN
0197-4580

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โœ Geneviรจve Evin; Aiqin Zhu; R.M. Damian Holsinger; Colin L. Masters; Qiao-Xin Li ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 175 KB ๐Ÿ‘ 1 views

## Abstract Proteolytic processing of the amyloid precursor protein by ฮฒ โ€and ฮณโ€secretases results in the production of Alzheimer's disease (AD) Aฮฒ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve