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Factors influencing the processing and function of the amyloid β precursor protein—a potential therapeutic target in Alzheimer's disease?

✍ Scribed by Christine M. Coughlan; Kieran C. Breen


Book ID
114129140
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
371 KB
Volume
86
Category
Article
ISSN
0163-7258

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve