P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy
β Scribed by Yasuyuki Honjyo; Yasuhiro Kawamoto; Shinichi Nakamura; Satoshi Nakano; Ichiro Akiguchi
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 107 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0001-6322
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## Abstract In cases of multiple system atrophy (MSA), glial cytoplasmic inclusions (GCI) were distributed randomly or present in large diffuse clusters (>1,600 ΞΌm in diameter) in most areas studied. These spatial patterns contrast with those reported for filamentous neuronal inclusions in the tauo
## Abstract Glial cytoplasmic inclusions are the pathological hallmark of multiple system atrophy. However, the molecular mechanisms underlying the formation of glial cytoplasmic inclusions remain unclear. Ξ±βSynuclein, a major component of glial cytoplasmic inclusions, has the ability to interact w