Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?
β Scribed by Hiroshige Fujishiro; Tae-Beom Ahn; Roberta Frigerio; Anthony DelleDonne; Keith A. Josephs; Joseph E. Parisi; J. Eric Ahlskog; Dennis W. Dickson
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 469 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0001-6322
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## Abstract In cases of multiple system atrophy (MSA), glial cytoplasmic inclusions (GCI) were distributed randomly or present in large diffuse clusters (>1,600 ΞΌm in diameter) in most areas studied. These spatial patterns contrast with those reported for filamentous neuronal inclusions in the tauo
## Abstract Glial cytoplasmic inclusions are the pathological hallmark of multiple system atrophy. However, the molecular mechanisms underlying the formation of glial cytoplasmic inclusions remain unclear. Ξ±βSynuclein, a major component of glial cytoplasmic inclusions, has the ability to interact w