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P3.62. Clinical significance of the dihydropyrimidine dehydrogenase and thmidylate synthase activity in oral cancer

✍ Scribed by Tsuzuki, M.; Satomi, T.; Watanabe, M.; chiba, H.


Book ID
119336996
Publisher
Elsevier Science
Year
2009
Weight
39 KB
Volume
3
Category
Article
ISSN
1744-7895

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30