P3.25 Satellite cell dependent growth and regeneration of skeletal muscle requires BMP signalling
✍ Scribed by H. Amthor; F. Relaix; E. Mouisel; A. Rochat; C. Beley; C. Hourdé; E. Schirwis; S. Alonso-Martin
- Book ID
- 116794597
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 39 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-8966
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We are reporting experiments that provide initial documentation of the action of TGF-beta on satellite cells. TGF-beta could be one of the important growth factors that act in concert to regulate the proliferation and differentiation of satellite cells in skeletal muscle. MATERIALS AND METHODS ##
Skeletal muscle satellite cells were cultured from mature rats and were treated in vitro with various combinations of transforming growth factor (TGF)-beta, fibroblast growth factor (FGF), and insulin-like growth factor I (IGF-l)~ In serum-free defined medium the following observations were made: TC