Skeletal muscle satellite cells were cultured from mature rats and were treated in vitro with various combinations of transforming growth factor (TGF)-beta, fibroblast growth factor (FGF), and insulin-like growth factor I (IGF-l)~ In serum-free defined medium the following observations were made: TC
Inhibition of skeletal muscle satellite cell differentiation by transforming growth factor-beta
β Scribed by Ronald E. Allen; Linda K. Boxhorn
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 685 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
β¦ Synopsis
We are reporting experiments that provide initial documentation of the action of TGF-beta on satellite cells. TGF-beta could be one of the important growth factors that act in concert to regulate the proliferation and differentiation of satellite cells in skeletal muscle.
MATERIALS AND METHODS
Materials
Medium, penicillin, streptomycin, and fungizone were purchased from Gibco (Grand Island, NY). Horse serum was collected from horses at the University of Arizona
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