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p27Kip1 Expression and grading of breast cancer diagnosed on cytological samples

✍ Scribed by Giancarlo Troncone; Ilenia Migliaccio; Alessia Caleo; Emiliano A. Palmieri; Antonino Iaccarino; Lucianna Sparano; Antonio Vetrani; Lucio Palombini

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 169 KB
Volume: 30
Category: Article
ISSN: 8755-1039
DOI: 10.1002/dc.20059

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The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder