Human lung cancer cells, including small cell lung carcinoma (SCLC), frequently lose expression of retinoic acid receptor β€ (RAR-β€) and are resistant to the growth inhibitory activity of all-trans retinoic acid (RA). To elucidate the role of RAR-β€ in the growth regulation of SCLC by retinoids, we re
Over-expression of p27kip1 induces growth arrest and apoptosis mediated by changes of pRb expression in lung cancer cell lines
β Scribed by Ichiro Naruse; Hideki Hoshino; Kunio Dobashi; Koichi Minato; Ryusei Saito; Masatomo Mori
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 168 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0020-7136
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Retinoids regulate the growth and differentiation of human tracheobronchial epithelial cells. In this study, we investigated the effects of all-trans-retinoic acid (trans-RA) and receptor class-selective retinoids on the growth and apoptosis of human lung cancer cell lines. Trans-RA significantly in