Cytological grading, apoptosis, and Bcl-2 protein expression in breast cancer
β Scribed by Manikkapurath Hemachandran; Raje Nijhawan; Kusum Joshi
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 266 KB
- Volume
- 26
- Category
- Article
- ISSN
- 8755-1039
- DOI
- 10.1002/dc.10105
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The expression of the pro-apoptotic proteins (Bax, Bak) and anti-apoptotic proteins (Bcl-2, Bcl-X, Mcl-1) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas. The results were correlated with tumour grade, expression of oestrogen receptor (ER) and p53 protein, and the apopto
favorable prognostic factors, including a lower number of positive lymph nodes, Texas. absence of p53 protein accumulation, estrogen receptor (ER) and progesterone 3 University of Texas M. D. Anderson Cancer receptor (PR) positivity, diploidy, and a lower proliferative rate. However, although Cente
Bcl-2 is a key protein involved in the control of apoptosis. Our previous studies on breast and endometrium indicated hormonal regulation of bcl-2 in these tissues. In the present work we have analyzed Bcl-2 and Bax protein expressions in MCF-7 and T47-D, 2 hormone-dependent breast-cancer cell lines
## BACKGROUND. Apoptosis-regulating genes have been shown to be important in the biology of prostate cancer. The aim of this study was to examine and correlate the expression of the apoptosis-regulating genes bcl-2, bax, and p53 with the frequency of apoptosis and rate of proliferation in benign p
Recent studies have shown that high levels of the apoptosisrelated proteins bcl-2 and bcl-x, increase, while over-expression of bcl-x, or bax decreases, resistance to drugs that induce apoptosis in some human cancer cells. In the present report, we investigated whether expression of these apoptosis-