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In vivo patterns of Bcl-2 family protein expression in breast carcinomas in relation to apoptosis

✍ Scribed by Rochaix, Philippe; Krajewski, Stanislaw; Reed, John C.; Bonnet, Fran�oise; Voigt, Jean-Jacques; Brousset, Pierre

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
261 KB
Volume
187
Category
Article
ISSN
0022-3417

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✦ Synopsis

The expression of the pro-apoptotic proteins (Bax, Bak) and anti-apoptotic proteins (Bcl-2, Bcl-X, Mcl-1) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas. The results were correlated with tumour grade, expression of oestrogen receptor (ER) and p53 protein, and the apoptotic index by combined morphology, immunohistochemistry, and a terminal UTP nick end labelling (TUNEL) procedure. Overall, Bcl-2, Bcl-X, Mcl-1, Bax, Bak, ER, and p53 were detected in 62, 75, 68, 75, 60, 68 and 26 per cent of the cases respectively, but at different levels in each case. A high apoptotic index was correlated with high tumour grade (p<0•001), overexpression of p53 (p<0•001), Bak expression (p<0•001), and low expression of Bcl-2 (p<0•001) and ER (p<0•001). No correlation was found between the apoptotic index and Bax, Bcl-X, and Mcl-1 immunostaining results. The expression of Bcl-2 and Bcl-X was correlated to that of ER. Overall, the results of this study strongly suggest that Bcl-2 and Bak expression is critical in regulating apoptosis in breast carcinomas.

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