p21WAF1/CIP1 and cancer: A shifting paradigm?
โ Scribed by Andrei L. Gartel
- Book ID
- 112010017
- Publisher
- IOS Press
- Year
- 2009
- Tongue
- English
- Weight
- 65 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0951-6433
- DOI
- 10.1002/biof.26
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In addition to the tumor suppressor gene p53, Cyclin Dependent Kinases (CDK) are well known to influence the cell cycle in normal human tissues and various neoplasias as well. The purpose of our present study was to evaluate the expression of the CDK-inhibitor p21/waf1/cip1 in colorectal cancer with
p21(CIP1/WAF1) is an inhibitor of cyclin-dependent kinases and, in normal tissues including squamous epithelia, has been associated with cell-cycle exit and differentiation. As shown in this pilot study, however, the majority of head-and-neck squamous-cell carcinomas (HNSCC) display aberrant p21(CIP