p19ARF links the tumour suppressor p53 t
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Palmero, Ignacio; Pantoja, Cristina; Serrano, Manuel
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Article
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1998
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Nature Publishing Group
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English
β 185 KB
p53 (refs 4, 8). This link between E2F-1 function and p14 ARF expression provides an explanation for the ability of oncogenic stimuli that could deregulate E2F-1 activity, such as defects in the RB pathway or activation of oncogenes such as Ras, E1A or Myc, to activate p53 (refs 9-12). Thus, abnorma