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p14ARF links the tumour suppressors RB and p53

✍ Scribed by Bates, Stewart; Phillips, Andrew C.; Clark, Paula A.; Stott, Francesca; Peters, Gordon; Ludwig, Robert L.; Vousden, Karen H.


Book ID
109697712
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
219 KB
Volume
395
Category
Article
ISSN
0028-0836

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p19ARF links the tumour suppressor p53 t
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p53 (refs 4, 8). This link between E2F-1 function and p14 ARF expression provides an explanation for the ability of oncogenic stimuli that could deregulate E2F-1 activity, such as defects in the RB pathway or activation of oncogenes such as Ras, E1A or Myc, to activate p53 (refs 9-12). Thus, abnorma

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