Novel Activators of the Tumour Suppressor p53
β Scribed by Nils Sunder-Plassmann; Athanassios Giannis
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 117 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1439-4227
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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana
## Abstract Activation of the p53 tumour suppressor is predicted to have therapeutically beneficial effects. Many current antiβcancer therapies activate the p53 response __via__ DNA damage. Nonβgenotoxic activation of the p53 pathway would open the way to longβterm and possibly prophylactic treatme