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p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

✍ Scribed by Roper, E.


Book ID
111709836
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
546 KB
Volume
2
Category
Article
ISSN
1469-221X

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## Abstract TGFΞ²1 acts as a potent negative regulator of the cell cycle and tumor suppressor in part through induction of cyclin dependent kinase inhibitors p15^ink4b^, p21, and p57. We previously showed that primary mouse epidermal keratinocytes (MEK) expressing a v‐__ras__^Ha^ oncogene undergo hy