Induction of p16ink4a and p19ARF by TGFΞ²
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Kinnimulki Vijayachandra; William Higgins; Jessica Lee; Adam Glick
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Article
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2008
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John Wiley and Sons
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English
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## Abstract TGFΞ²1 acts as a potent negative regulator of the cell cycle and tumor suppressor in part through induction of cyclin dependent kinase inhibitors p15^ink4b^, p21, and p57. We previously showed that primary mouse epidermal keratinocytes (MEK) expressing a vβ__ras__^Ha^ oncogene undergo hy