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Cell-cycle arrest and p53-independent induction of apoptosis in vitro by the new anticancer drugs 5-FdUrd-P-FdCydOct and dCydPam-P-FdUrd in DU-145 human prostate cancer cells

โœ Scribed by Rosanna M. C. Cattaneo-Pangrazzi; Herbert Schott; Heidi Wunderli-Allenspach; Barbara Rothen-Rutishauser; Maja Guenthert; Reto A. Schwendener

Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
334 KB
Volume
126
Category
Article
ISSN
1432-1335

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๐Ÿ“œ SIMILAR VOLUMES

The novel heterodinucleoside dimer 5-FdU
The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145
โœ R.M.C. Cattaneo-Pangrazzi; H. Schott; R.A. Schwendener ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 323 KB ๐Ÿ‘ 2 views

BACKGROUND. We analyzed the cytotoxic properties of the new heterodinucleoside phosphate dimer 5-FdU-NOAC, which is composed of the cytotoxic drugs 5-FdU and N 4octadecyl-1-โค-D-arabinofuranosylcytosine (NOAC) against human prostate tumor cells. METHODS. 5-FdU-NOAC effects on cell proliferation, cell