p16INK4A promoter hypermethylation of gastric cancers and precursor lesions
โ Scribed by Yang, Chang-Hun; Kim, Dae-In; Lee, Goo; Suh, Jung-Il; Lee, Chang-Woo; Jang, Tae-Jung; Lee, Kyu-Chun; Choi, Myung-Gyu; Kim, Won-Ho
- Book ID
- 124147892
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 178 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0016-5085
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The p16(INK4a) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including gastric cancers. However, p16(INK4a) promoter hypermethylation in the surrounding non-tumorous tissues of gastric cancers has not been studied in detail. We therefore examined 46
## Abstract Inactivation of p16INK4a gene through promoter hypermethylation has been frequently observed in non small cell lung cancer; however, various studies have shown a controversial correlation between p16INK4a hypermethylation and cigarette smoking. Our recent report showed that human papill