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p16INK4a-induced senescence is disabled by melanoma-associated mutations

โœ Scribed by Sebastian Haferkamp; Therese M. Becker; Lyndee L. Scurr; Richard F. Kefford; Helen Rizos


Book ID
111199508
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
490 KB
Volume
7
Category
Article
ISSN
1474-9718

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Melanoma-associated germline mutations affecting the tumor suppressor and cyclin-dependent kinase (CDK) inhibitor, CDKN2A/p16INK4a, have been identified in over 100 melanoma-prone families worldwide. To predict the melanoma risk for carriers of specific mutations, mutant p16INK4a can be tested in bi