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p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma

โœ Scribed by Fujimoto, Akihide; Morita, Reiji; Hatta, Naohito; Takehara, Kazuhiko; Takata, Minoru


Book ID
110062220
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
498 KB
Volume
18
Category
Article
ISSN
0950-9232

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Homozygous deletion of the p16INK4a and
โœ Wagner; Wagner; Briedigkeit; Goos ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 453 KB

Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutations