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p14ARF regulates E2F activity

✍ Scribed by Mason, Sarah L; Loughran, Öonagh; La Thangue, Nicholas B

Book ID
110066709
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
383 KB
Volume
21
Category
Article
ISSN
0950-9232

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p14ARF interacts with E2F factors to for
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✍ Hai-Jun Zhang; Wen-Juan Li; Yan-Yan Gu; Shu-Yan Li; Guo-Shun An; Ju-Hua Ni; Hong πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 320 KB

## Abstract Primarily, E2F factors such as E2F1, ‐2, and ‐3 stimulate cell‐cycle progression, while ARF tumor suppressor mediates growth suppression. The __ARF__ gene can be induced by oncogenic signal through activating E2F‐dependent transcription. In turn, ARF may target E2F for its degradation v