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Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

✍ Scribed by Komori, Hideyuki; Enomoto, Mitsuru; Nakamura, Masataka; Iwanaga, Ritsuko; Ohtani, Kiyoshi

Book ID
110031223
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
267 KB
Volume
24
Category
Article
ISSN
0261-4189

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## Abstract Primarily, E2F factors such as E2F1, ‐2, and ‐3 stimulate cell‐cycle progression, while ARF tumor suppressor mediates growth suppression. The __ARF__ gene can be induced by oncogenic signal through activating E2F‐dependent transcription. In turn, ARF may target E2F for its degradation v