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P13 Differential effects of doxorubicin treatment on the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

✍ Scribed by D. Hershk; O. Bar On; M. Shapira

Book ID: 114315931
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 49 KB
Volume: 16
Category: Article
ISSN: 0960-9776
DOI: 10.1016/s0960-9776(07)70078-4

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio