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The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

✍ Scribed by Ma'anit Shapira, Eli Kakiashvili, Tzur Rosenberg, Dan D Hershko


Book ID
120700206
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
684 KB
Volume
8
Category
Article
ISSN
1465-5411

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## Abstract Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the r