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Expression of the Ubiquitin Ligase Subunit Cyclin Kinase Subunit 1 and its Relationship to S-Phase Kinase Protein 2 and p27Kip1 in Prostate Cancer

✍ Scribed by Shapira, Ma’anit; Ben-Izhak, Ofer; Slotky, Merav; Goldin, Oleg; Lahav-Baratz, Shirly; Hershko, Dan D.

Book ID
123090289
Publisher
Lippincott Williams and Wilkins
Year
2006
Tongue
English
Weight
240 KB
Volume
176
Category
Article
ISSN
0022-5347

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Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma : Relation to p27Kip1 and its Ubiquitin Ligase Subunit, S Phase Kinase Protein 2
✍ Ma'anit Shapira; Ofer Ben-Izhak; Bishara Bishara; Boris Futerman; Ira Minkov; Mi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 2 views

## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio