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P104. Novel NONO-NSAIDs possessing a nitric oxide donor diazeniumdiolate moiety

โœ Scribed by Carlos A. Velazquez; Edward E. Knaus; Praveen Rao Perampali


Book ID
116790204
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
63 KB
Volume
14
Category
Article
ISSN
1089-8603

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Celecoxib prodrugs possessing a diazen-1
โœ Khaled R.A. Abdellatif; Morshed A. Chowdhury; Carlos A. Velรกzquez; Zhangjian Hua ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 284 KB

A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2diolato ammonium salt, and its O 2 -methyl and O 2 -acetoxyethyl derivatives, nitric oxide (NO) donor moieties were attached directly to an aryl carbon on a celecoxib template. The percentage of NO rel