P103 a chemoenzymatic route both enantiomers of the macrocyclic lactone lasiodiplodin
β Scribed by Schulte, B.; Bracher, F.
- Book ID
- 123580472
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 90 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0928-0987
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## Abstract The macrocyclic lactone (__S__)βcurvularin (10) and its enantiomer __ent__β10 were prepared in an enantiodivergent manner from (__S__)βmethyl 7βhydroxyoctanoate (4), which was easily obtained on two different ways. Esterification of 4 under either retention or inversion of the chiral ce
An Enantiodivergent Synthesis of Both Enantiomers of the Macrocyclic Lactone Curvularin. -An enantiodivergent synthesis of curvularin (S)-(IX) and its enantiomer is presented based on the esterification of key intermediate (S)-(V) under either retention or inversion of the chiral center leading to