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P1-341: Are common variants in APP risk factors for late-onset Alzheimer’s disease?

✍ Scribed by Petra Nowotny; Xavier Simcock; Anthony L. Hinrichs; Sarah Bertelsen; Scott Smemo; Kevin Mayo; John S.K. Kauwe; John C. Morris; Alison Goate

Book ID
118462790
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
56 KB
Volume
2
Category
Article
ISSN
1552-5260

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Association studies testing for risk for
Association studies testing for risk for late-onset Alzheimer's disease with common variants in the β-amyloid precursor protein (APP)
✍ Petra Nowotny; Xavier Simcock; Sarah Bertelsen; Anthony L. Hinrichs; John S.K. K 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 2 views

## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer