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P1-308: Association of variants in Aβ processing genes with late onset Alzheimer’s disease (LOAD)

✍ Scribed by Linda H. Younkin; Toros Dincman; Johann Lok; Manu Raam; Fanggeng Zou; Minerva Carrasquillo; Li Ma; Ron Budjak; Samuel Younkin; Ronald Petersen; Neill Graff-Radford; Steven Younkin

Book ID: 118462757
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 66 KB
Volume: 2
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2006.05.686

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## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer