𝔖 Bobbio Scriptorium
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P-445 A suicide gene therapy of metastasized liver tumors

✍ Scribed by T Matsuyama; Y Koshita; Y Lu; H Neda; M Hirayama; Y Sato; J Teramoto; N Watanabe; Y Niitsu; H Wakimoto; H Hamada


Book ID
113402332
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
121 KB
Volume
3
Category
Article
ISSN
0928-4346

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Tumor cells genetically modified with the herpes simplex virus thymidine kinase (HSV-tk) gene in combination with ganciclovir (GCV) demonstrate a ''bystander effect''. Previous attempts to enhance the bystander tumor killing by combining cytokine genes with HSV-tk/GCV have met with varying results.