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A cancer gene therapy approach through translational control of a suicide gene

✍ Scribed by DeFatta, Robert J; Chervenak, Robert P; De Benedetti, Arrigo


Book ID
110018904
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
858 KB
Volume
9
Category
Article
ISSN
0929-1903

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## Abstract Two technical hurdles, gene delivery and target specificity, have hindered the development of effective cancer gene therapies. In order to circumvent the problem of tumor specificity, the suicide gene, HSV‐1 thymidine kinase (HSV‐Tk), was modified with a complex 5β€² upstream‐untranslated