Hepatitis C virus (HCV) load is one of the most important predictive factors of response to interferon treatment. However, little is known about the mode and determinants of viremia. The mode of viremia was investigated in 78 patients with chronic HCV genotype 1b infection during 1-2 years follow up
P-275 Amino acid substitutions in NS5A region of HCV-1B are related to its sensitivity to interferon
โ Scribed by I Sakuma; N Enomoto; T Murakami; Y Asahina; C Yamamoto; M Kurosaki; N Izumi; F Marumo; C Sato
- Book ID
- 113402160
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 116 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0928-4346
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GB virus C (GBV-C) is related to hepatitis C virus (HCV) and has a similar genomic structure. Some predictors for the efficacy of interferon (IFN) therapy on HCV have been reported: genotype, viral load, IFN dose, and the amino acid substitutions in the NS5A region, designated as the interferon sens
of patients with a high likelihood of response to IFN-b. In chronic hepatitis C virus (HCV) infection, geno-(HEPATOLOGY 1997;25:750-753.) types other than genotype 1b of HCV (HCV-1b) and low serum HCV-RNA levels are known to be associated with favorable outcome of interferon alfa (IFN-a) therapy. In