## Abstract The aim of this study was to compare the efficacy of highโdose interferon (IFN)โฮฑโ2b with standard dose of IFNโฮฑโ2b in combination with ribavirin (RBV) for patients with chronic hepatitis C virus (HCV) infection, and to investigate the predictive factors associated with virological resp
โฆ LIBER โฆ
Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy
โ Scribed by Akuta, Norio; Suzuki, Fumitaka; Hirakawa, Miharu; Kawamura, Yusuke; Sezaki, Hitomi; Suzuki, Yoshiyuki; Hosaka, Tetsuya; Kobayashi, Masahiro; Kobayashi, Mariko; Saitoh, Satoshi
- Book ID
- 111891835
- Publisher
- S. Karger AG
- Year
- 2012
- Tongue
- English
- Weight
- 837 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0300-5526
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Genetic variation near the IL28B gene and substitution of amino acid (aa) 70 and 91 in the core region of hepatitis C virus (HCV) genotype 1b can predict the response to pegylated interferon (PEG-IFN)/ribavirin combination therapy, but its impact on triple therapy of telaprevir/PEG-IFN/ribavirin is