✦ LIBER ✦

Oxidative metabolism of polymorphonuclear leukocytes (PMN) in patients with IgA nephropathy

✍ Scribed by Hung-Chun Chen; Yasuhiko Tomino; Yutaka Yaguchi; Mitsumine Fukui; Ken-ichi Yokoyama; Asako Watanabe; Hikaru Koide

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 485 KB
Volume: 6
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860060108

No coin nor oath required. For personal study only.

✦ Synopsis

The production of hydrogen peroxide (H202) by neutrophilic polymorphonuclear leukocytes (PMN) after stimulation and the infiltration of PMN in glomeruli were determined in 20 patients with primary IgA nephropathy. The H202 production of PMN after the stimulation was measured with a spectrophotometer using horseradish peroxidase as substrate. The results were as follows: 1) when PMN were pretreated with cytochalasine B, H202 production after stimulation with heataggregated IgG (IgG) or serum-treated zymo-san (STZ) was significantly higher in patients with IgA nephropathy than in controls, and 2) there was an increased amount of PMN localized in glomeruli in patients with IgA nephropathy using immunofluorescence of monoclonal anti-PMN antibody.

It appeared that the increased renal infiltration of PMN which have a high potential for production of reactive oxygen species might induce the glomerular injuries in patients with IgA nephropathy.

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