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Overexpression ofBaxsensitizes breast cancer MCF-7 cells to cisplatin and etoposide

✍ Scribed by Chouhei Sakakura; Elizabeth A. Sweeney; Tsutomu Shirahama; Yasuyuki Igarashi; Sen-ichiroh Hakomori; Hiroyuki Tsujimoto; Tsutomu Imanishi; Masaharu Ogaki; Takayuki Ohyama; Junya Yamazaki; Akeo Hagiwara; Toshiharu Yamaguchi; Kiyoshi Sawai; Toshio Takahashi

Book ID
112741816
Publisher
Springer
Year
1997
Tongue
English
Weight
491 KB
Volume
27
Category
Article
ISSN
1436-2813

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Overexpression of bax sensitizes human b
Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
✍ Chouhei Sakakura; Elizabeth A. Sweeney; Tsutomu Shirahama; Yasuyuki Igarashi; Se πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 French βš– 553 KB

Resistance to apoptosis plays an important role in tumors that are refractory to chemotherapy and ionizing radiation (IR). bax, which forms a heterddimer with bcl-2 and accelerates apoptosir, is not, or only weakly. expremed in most human breast cancer cells, and weak bax expression is considered to