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Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7

โœ Scribed by Farhad Vesuna; Paul Winnard Jr.; Venu Raman; Carlotta Glackin


Book ID
113512906
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
302 KB
Volume
167
Category
Article
ISSN
0165-4608

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Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCFโ€7 cells compared with HeLa. BRCA1 expression was lower in MCFโ€7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromo