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Overexpression of p53 gene in head-and-neck cancer, linked with heavy smoking and drinking

✍ Scribed by Field, J.K.; Spandidos, D.A.; Stell, P.M.


Book ID
122916486
Publisher
The Lancet
Year
1992
Tongue
English
Weight
285 KB
Volume
339
Category
Article
ISSN
0140-6736

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Overexpression of P53 in head and neck c
✍ David L. Watling; Dr. Allen M. Gown; Dr. Marc D. Coltrera πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 766 KB

The putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene-complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of