The putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene-complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of
✦ LIBER ✦
Overexpression of p53-Related Proteins Predicts Rapid Growth Rate of Head and Neck Cancer
✍ Scribed by Staffan Edström; Elisabet Cvetkovska; Thomas Westin; Cecilia Young
- Book ID
- 110082569
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 108 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0023-852X
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We investigated the prognostic significance of p53-gene mutation (exon 5-9) and bcl-2-protein expression in primary squamous-cell carcinoma of the head and neck (HNSCC) treated by curative radiotherapy (RT). Primary squamouscell carcinomas for analysis were obtained from 85 consecutive head-and-neck