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Overexpression of ErbB2 Blocks Taxol-Induced Apoptosis by Upregulation of p21Cip1, which Inhibits p34Cdc2 Kinase

โœ Scribed by Dihua Yu; Tong Jing; Bolin Liu; Jun Yao; Ming Tan; Timothy J McDonnell; Mien-Chie Hung


Book ID
117736129
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
326 KB
Volume
2
Category
Article
ISSN
1097-2765

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ErbB2 overexpression in human breast car
โœ Wentao Yang; Kristine S. Klos; Xiaoyan Zhou; Jun Yao; Ying Yang; Terry L. Smith; ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 753 KB

## Abstract ## BACKGROUND Clinical investigations have shown that in patients with breast carcinoma, tumors that overexpress the __erb__โ€B2 gene are less responsive to certain chemotherapy regimens compared with tumors that express low levels of __ErbB2__, suggesting that ErbB2 overexpression may