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Phosphorylation on Tyrosine-15 of p34Cdc2 by ErbB2 receptor tyrosine kinase inhibits p34Cdc2 activation and is involved in resistance to taxol-induced apoptosis

Book ID: 117659884
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 153 KB
Volume: 38
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(02)81195-9

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## Abstract ## BACKGROUND Clinical investigations have shown that in patients with breast carcinoma, tumors that overexpress the __erb__‐B2 gene are less responsive to certain chemotherapy regimens compared with tumors that express low levels of __ErbB2__, suggesting that ErbB2 overexpression may